Postpartum hemorrhage is the most serious complication in obstetrics. Postpartum hemorrhage occurs in approximately 4% of vaginal deliveries and estimates are that it caused significant morbidity & 25% of all the maternal child birth related deaths. The greatest number of maternal death from hemorrhage is due to postpartum hemorrhage, which is all most entirely a preventable condition by judicial & timely use of uterotonic agents in prevention of postpartum hemorrhage. In order to assess the efficacy of various uterotonic agents in management of third stage of labour parameters such as amount of blood loss duration of 3rd stage of labour and mean fall in hemoglobin 48 hour after the delivery were taken into account. All these parameters were explained with the help of statistical analysis. The subject matter has been presented in simple language. This book can serve as a good reference material for the students, teacher/scientist, researcher, policy makers and staff of medical field.