Diabetes mellitus constitutes a major cardiovascular risk factor with associated increased morbidity and mortality amongst affected women. Recently it has been shown, that although initially thought to be rare, cardiovascular disease and associated complications is on the rise among female Nigerians. However, studies on the effect of hypertension on the ECG parameters and evidence to support the related complications and particularly the cardiovascular complications of diabetes and/or hypertension among female diabetic subjects in our environment (Nigeria) are still relatively scanty and not well documented. The present study determined changes and complications in a cohort of susceptible ECG and the occurrence, prevalence, characterization of ECG patterns and abnormalities in female hypertensive diabetics as compared to normotensive diabetics. This book has been able to document the pattern of ECG changes in female hypertensive diabetic Nigerians compared to normotensive diabetics, indicating that both subject groups are at higher risk of developing cardiovascular disease complications which might be a reflection of environmental associated increases in body fat.