Drug targeting has the potential to reduce side effects and to increase pharmacological response. The colon can be liable to numerous pathological conditions, such as constipation, Crohn''s disease, ulcerative colitis, carcinomas and infections. Ulcerative colitis (UC) is a chronic inflammation of the large intestine. It would be ideal to treat UC with topical corticosteroids that are poorly bioavailable to minimize systemic side effects.