This issue of Clinics in Geriatric Medicine, guest edited by Seymour Katz, MD, is devoted to Gastroenterology. Articles in this outstanding issue include Constipation: Understanding Mechanisms and Management, Vaccination status/Prophylaxis with GI Diseases, Reflux and Acid Peptic Diseases in Elderly, Anorectal Physiology/Pathophysiology in Elderly, Endoscopic Challenges, Colorectal Cancer of Elderly, Pancreatic Disease, GI Drug Interactions, Microscopic/Collagenous Colitis, Hepatitis B and C, IBD of the Elderly, Imaging Techniques in GI Diseases of Elderly, Dysphagia/Swallowing disorders of Elderly, and Clostridium difficile infection in the elderly.