A descriptive account based on the field of health risk assessment has been presented in this elaborative book. It consists of a compilation of various health risk assessments for existing and rising hazards spanning a continuum. Psychoactive drug usage in drivers of delivery trucks and using look-back risk evaluation for accidental syringe re-use in healthcare settings are some of the case studies on existing risks covered in this book. Case studies regarding rising risks include precautionary actions to protect blood supplies, deposition of nanoparticles in the lung, and the epistemic issues related to genetically enhanced organism risk evaluations. The book also highlights progressing health risk assessment analysis through a post-genomics lens and elucidates the case studies on personalized genomics, advancing in silico models for risk evaluation and novel data analyses.