The autonomous management of spacecraft is to use modern control technologies such as artificial intelligence to establish a remote intelligent body on the spacecraft, so that the spacecraft can complete its flight tasks by itself. Its goal is to accurately perceive its own state and external environment without relying on external information injection and control or rely on external control as little as possible, make various appropriate decisions based on this information and user tasks, and be able to autonomously control spacecraft to complete various tasks. High-Reliability Autonomous Management Systems for Spacecraft conducts research on three levels of self-management, including: 1) Autonomous health management of spacecraft means that the spacecraft can monitor and sense its own state, and can autonomously detect, isolate and recover from faults, 2) Autonomous mission management of spacecraft means that the spacecraft can directly receive the mission, formulate a reasonable plan according to the current state and working environment of the spacecraft, and convert the mission into a specific sequence of instructions, 3) Spacecraft autonomous data management means that the spacecraft processes a large amount of raw data and extracts useful information, and autonomously executes or changes flight tasks according to the processing situation.