This second edition is a result from a worldwide surge of interest in antiphospholipid syndrome. This disease, also known as Hughes Syndrome, affects all organs of the body including the placenta, and touches all areas of medicine. Many publications have shown that APS causes miscarriage, strokes, heart attacks and teenage epilepsy, as well as being a major, treatable cause of migraine and memory loss. Hughes' Syndrome- A Patient’s Guide, Second Edition, will see many of the illustrations updated as well as an increase in the number of figures within the chapters, to help the reader understand and treat this disease. Although labelled a 'patient's guide', the text and presentation is aimed at a wide spectrum of health care professionals.