This work is provided a lot of examples in different fields of chemical engineering to design accurate solutions by using HYSYS soft ware. Chapter 1 includes basic rules of HYSYS soft ware to inputs data and conditions of the processes. Chapter 2 gives deep explain about distillation column to install it in chemical plant. This book shows in the other chapters' scientific steps to install for different separation process using different examples and also, provides different examples in heat transfer, mass transfer, modeling and chemical reaction for CSTR reactor to solve these problems depends on HYSYS soft ware.