Science has long been considered the very definition of modernity, the source of the empiricism and skepticism, openness and civility that distinguishes modern societies from previous social orders. Lately this view of science has come under intense scrutiny, as historians, philosophers, and scientists themselves have begun to ask fundamental questions about the institution of science. In this collection of invigorating interviews, David Cayley talks to some of the world's most provocative thinkers about the nature of scientific knowledge. Touching upon a rich array of subjects, he probes how our understanding of science has begun to shift and alter our view of the world.