This issue of Interventional Cardiology Clinics, edited by Jorge Gonzalez and Matthew Price, will span a number of essential topics surrounding Imaging in Intervention. Subjects discussed include: Multimodality Imaging for Transcatheter Mitral Valve Replacement, CT Assessment for Transcatheter Aortic Valve Replacement, Imaging Evaluation and Interpretation for Vascular Access for TAVR, Imaging Evaluation for the Detection of Leaflet Thrombosis after TAVR, CT Imaging Guidance for WATCHMAN LAA Closure, Myocardial viability testing to guide coronary revascularization, Intravascular Ultrasound For Guidance and Optimization of Percutaneous Coronary Intervention, CT-FFR to guide coronary angiography and intervention, Multimodality imaging of the tricuspid valve for assessment and guidance of transcatheter repair, and Three-dimensional printing for structural heart intervention planning, among others.