This issue of Perioperative Nursing Clinics, Guest Edited by George Allen, features subject topics such as: OR Attire's Potential for Infection Transmission, Strategies for Preventing Sharps Injuries, Managing Patients with MDROs - Implementing Isolation Procedures in the Perioperative Setting, Anesthesia Care Providers - Identifying/Mitigating Potential for Infection Transmission, Urinary Catheter Insertion and Care in the Perioperative Setting, Hand Hygiene and the Surgical Team, Outlining Effective Strategies for Preventing SSI, Environmental Sanitation - Review of New Technologies, Reprocessing Instruments: Focus on Eye Surgery and TASS (Toxic Anterior Segment Syndrome), Skin Prepping to Maximize Positive Outcomes, Improving the process of supplying instruments from central processing to the OR using the LEAN method, Using Performance Improvement Methodology in Finding the Cause of Increase Biological Cultures in the Operating Room and Solutions for Corrections.