This book constitutes the refereed proceedings of the 13th Asian Conference on Intelligent Information and Database Systems, ACIIDS 2021, held in Phuket, Thailand, in April 2021.*The 67 full papers accepted for publication in these proceedings were carefully reviewed and selected from 291 submissions. The papers of the first volume are organized in the following topical sections: data mining methods and applications, machine learning methods, decision support and control systems, natural language processing, cybersecurity intelligent methods, computer vision techniques, computational imaging and vision, advanced data mining techniques and applications, intelligent and contextual systems, commonsense knowledge, reasoning and programming in artificial intelligence, data modelling and processing for industry 4.0, innovations in intelligent systems.*The conference was held virtually.