International Review of Cytology presents current advances and comprehensive reviews in cell biology both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume address cell biology of membrane trafficking in human disease, the biology of the gaucher cell, intracellular signals and events activated by cytokines of the TNF superfamily, cellular and molecular biology of orphan G-protein coupled receptors, organization and function of the actin, cytoskeleton in developing root cells.