In this issue of Interventional Cardiology Clinics, guest editor Dr. Allen Jeremias brings his considerable expertise to the topic of Intracoronary Physiology and Its Use in Interventional Cardiology. Assessment of intra-coronary physiology can guide percutaneous coronary intervention and is often used for angiographically borderline stenoses. There is now increasing evidence to suggest that more routine use can improve clinical outcomes. In this issue, top experts bring you fully up to date in this key area of interventional cardiology. Contains 13 practice-oriented topics including updates in coronary physiology: what about all the negative trials?, physiology for post-PCI assessment, physiology and intravascular imaging co-registration, CT-derived physiology assessment, targeted therapies for microvascular disease, and more.  Provides in-depth clinical reviews on intracoronary physiology and its use in interventional cardiology, offering actionable insights for clinical practice.  Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.