Phosphorylation and O-linked glycosylation of mammalian proteins include structural and functional changes that are most often transitory and difficult to follow. In silico prediction procedure for these PTMs are valuable to forsee for disease prognosis and treatment. In this study genetic control of Thr codons in mammalian proteins is investigated. Specifically phosphorylation and O-GlcNAc sites were explored. The tools used for these analyses are dbPTM, Uniprot, SMS codon plot, Ying-O-Yang, MAPRes and Weblogo.