The purpose of the work is to provide information regarding the diseases that to microbial disease, which are common and dangerous to man in his daily activities, troubling man and animals in recent years during 21st century. we have quoted some of disease, symptoms, prevention, causative, how serious it is to mankind and this book will provide the basic information of disease which can highlight the possible information in the science. This project may help the researcher and students and those who study the clinical biology,