This issue of Surgical Oncology Clinics of North America, edited by Adam Berger, is devoted to Melanoma. Articles in this issue include: Current Staging and Prognostic Factors in Melanoma, Melanoma Pathology, Surgical Treatment of Primary and Recurrent Melanoma, Sentinel Lymph Node Mapping and Its Importance for Melanoma in the 21st Century, Lymph Node Dissection for Stage 3 Melanoma, Metastasectomy for Stage IV Melanoma, Local/Injectional Therapies for Satellite and In-Transit Disease, Regional Therapies for In-Transit Disease, Role for Radiation Therapy in Melanoma, Update on Immunotherapy for Melanoma, Targeted Therapies in Melanoma, and Evidence for Long-Term Follow-up of Melanoma Patients.