Modeling and simulation (M&S, ) is increasingly becoming a central activity in the development of new and existing systems because it enables designers and researchers to manage systems complexity and investigate system behaviors through virtual representation. To date, a handbook that includes established M&S, practices is not available in the systems engineering community. This multi-contributed reference book provides the M&S, practices for supporting systems engineering in diverse domains. Readers can also identify their systems engineering needs and adapt these practices to suit their specific application domain, thus avoiding redefining practices from scratch.