This issue of Hematology/Oncology Clinics of North America, devoted to Multiple Myeloma, is edited by Dr. Kenneth C. Anderson. Articles in this issue include: Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma, Diagnosis and Risk Stratification in Myeloma, Treatment of Newly Diagnosed Transplant Eligible Patients, Treatment of Newly Diagnosed Transplant Ineligible Patients, Treatment of Relapsed/Refractory Myeloma, Maintenance Therapy, Novel Targeted Therapies, Novel Immune-based Therapies, Allotransplantation in Myeloma, and Waldenstrom's Macroglobulinemia.