Glucocorticoids have been acknowledged as one of the most essential steroid hormones, for its therapeutic benefits have been used in clinical treatments, particularly in anti-inflammation cases. Glucocorticoids controls several processes in the body also with the mobilization of energy stores, immune system, gene expression, and upholding of the homeostasis as well as the stress response, this is not unexpected that the theory of "glucocorticoids" is talked about in almost all medical books that aims on definite organs or systems such as the cardiovascular system, the immune system, and the neuroendocrine system. This book aims to reveal the newest researches linked to glucocorticoids, from the laboratory or from clinical case studies, and targets to create a scope of balancing the therapeutic benefits and problems caused by glucocorticoids.