This book constitutes the proceedings of the Second International Conference on Optimization, Learning Algorithms and Applications, OL2A 2022, held in Bragança, Portugal, in October 2022.

The 53 full papers and 3 short papers were thoroughly reviewed and selected from 145 submissions. They are organized in the topical sections on Machine and Deep Learning, Optimization, Artificial Intelligence, Optimization in Control Systems Design, Measurements with the Internet of Things, Trends in Engineering Education, Advances and Optimization in Cyber-Physical Systems, and Computer vision based on learning algorithms.