Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, providing them with critical working knowledge on basic reactions, stereochemistry, and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. The organization of this new book has been improved to better serve students and professors, and to accommodate important updates in the field. . The first two chapters provide an introduction to functional group exchange reactions, and are followed by chapters reviewing protecting groups, strategies, and basic organic transformations such as oxidation and reduction. The book then covers the reactions required to actually complete a synthesis, exploring carbon-carbon bond formation reactions, pericyclic reactions, and methods to ¿disconnect' a bigger molecule into simpler building blocks. . Finally, a chapter on combinatorial chemistry has been expanded to include valuable and forward-looking content on process chemistry and green organic chemistry. Slide presentations and answer keys are also available to support instructor use.