This issue of Primary Care: Clinics in Office Practice, guest edited by Drs. Alan R. Roth, Peter A. Selwyn, and Serife Eti, is devoted to Palliative Care. Articles in this important issue include: Introduction to Hospice and Palliative Care, Hospice for the Primary Care Physician, Pain Assessment and Management, Non-Pain Symptom Management, Communication Skills: Delivering Bad News, Conducting a Goals of Care Family Meeting, and Advance Care Planning, Psychosocial Issues and Bereavement, Ethical and Legal Considerations in End of Life Care, Cultural, Religious, and Spiritual Issues in Palliative Care, Palliative Care Approach to Chronic Diseases (CHF/COPD/ESLD/ESRD), Palliative Care in HIV/AIDS, Palliative Care in the Elderly (Dementia, Neurodegenerative Disorders, Functional Decline/Frailty), and Pediatric Palliative Care.