Medication related problems (MRPs) are on the rise, and are a major concern especially for healthcare professionals as they pose a significant risk to patients leading to hospitalisation and increasing the healthcare expenditure. As the drug therapy is becoming more complex, the challenge of prescribing appropriate medication is increasing. In clinical settings, a wide range of MRPs might arise due to various causes. However, optimization of drug therapy may, by preventing MRPs, influence healthcare cost, potentially reduce morbidity and mortality, and enhance patient''s quality of life. Although many studies have detailed the MRPs and their consequences, only few published studies assessed the impact of clinical pharmacist-initiated changes to drug therapy. The work described assessed and quantified the pharmacist-initiated changes to drug therapy and their impact on cost savings. The results of the study would shed some vital data on medication related problems and the impact of pharmacist-initiated changes to drug therapy on cost savings, and should be of interest and useful to researchers and professionals in healthcare settings especially the pharmacists.