The use of minerals and plant-based medicines are believed to date back to prehistoric medicine. The first use of drugs to treat cancer, however, was in the early 20th century, although it was not originally intended for that purpose. Mustard gas was used as a chemical warfare agent during World War I and was studied further during World War II. During a military operation in World War II, a group of people were accidentally exposed to mustard gas and were later found to have very low white blood cell counts. This book explains a detail about the developments of anticancer drugs from plants to synthetic and from old times to recent. This book is a collection of various reviews which helps readers of all ares to understand