This book presents select proceedings of the International Conference on Applied Mathematics in Science and Engineering (AMSE 2019). Various topics covered include computational fluid dynamics, applications of differential equations in engineering, numerical methods for ODEs and PDEs, mathematical modeling and analysis of biological systems, optimal control and controllability of differential equations, fractional calculus and its applications, nonlinear analysis, and functional analysis. This book will be of interest to researchers, academicians and students in the fields of applied sciences, mathematics and engineering.