This comprehensive book covers all clinical aspects of renal replacement therapy in critical care. It focuses in particular on continuous renal replacement therapy including detailed and updated information on regional citrate anticoagulation, antibiotic dosing, nutrition, electrolyte monitoring, and novel dialysis membranes. Chapters are dedicated to the Stewart acid-base approach which offers a different but practical insight on metabolic complications during (continuous) renal replacement therapy, and the current status of blood purification during sepsis. Specific modalities such as plasmafiltration and treatment of acute poisoning are also discussed.