Mitty Andersen knows that rising blues star Bobby Tarleton didn't die of a heroin overdose. He'd blown enough blues harmonica notes with Bobby to know that he would never let anything get in the way of his music. So when he gets the news in the middle of his blues set at Little Queenie's, he suspects a cover-up-and he's determined to put his ex-investigative reporter skills to work to find out what really happened. Mitty hits the blues circuit with his "partner in chime, " Pete Bolden, and rounds up a posse disguised as a blues band. They gig the juke joints and blues bars throughout Southeast Texas and Louisiana, hoping to uncover the truth about Bobby T's death. It doesn't take long for Mitty to figure out that Bobby T just might be the latest in a decades-long string of serial murders aimed at eliminating "those who play the Devil's music."
Now Mitty must race against the clock to put an end to the madness before another harmonica player succumbs to a deranged psychopath who has managed to avoid capture for far too long.