In this issue of Infectious Disease Clinics of North America, guest editor Dr. Jeanne Marrazzo brings her considerable expertise to the topic of Sexually Transmitted Infections. The CDC approximates that 20% of Americans have experienced a sexually transmitted infection (STI), and the World Health Organization has estimated that over 340 million people live with STIs worldwide every year. In this issue, top experts  provide important updates in this area, with goals to provide the relevant clinical information to aid physicians in prevention, diagnosis, and management. Contains 14 practice-oriented topics including syphilis: a modern resurgence, update in management and prevention of chlamydial infections, non-herpes and non-syphilis causes of genital ulcer disease (including monkeypox, LGV, chancroid), diagnostic advances in sexually transmitted infections, immunizations for sexually transmitted infections, and more.  Provides in-depth clinical reviews on sexually transmitted infections, offering actionable insights for clinical practice.  Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.