This issue offers a valuable update in the fast-moving specialty of sleep medicine. Topics covered include: The Neurobiology of Sleep, Adult Obstructive Sleep Apnea, Central Sleep Apnea (including complex sleep apnea and ASV), Pediatric Sleep-Related Breathing Disorders, Hypoventilation Syndromes, Metabolism in OSA, Cardiovascular Consequences of Sleep Apnea, Home Sleep Apnea Testing, Insomnia, Excessive Sleepiness, Narcolepsy, Restless Leg Syndrome and Movement Disorders, Parasomnia, Circadian Rhythm Sleep Disorders, Medication Effects on Sleep, and Polysomnography.