The SMART Approach to Spine Clinical Research book is designed to teach the principles and methods of evaluating and performing clinical research for a spine-related audience of a wide range of experience levels. The material is presented in an interesting and uncomplicated manner while including real-life examples of research questions or challenges and how they may be addressed successfully. To make reading of such a text different and appealing, the book presents case examples of study questions posed by spine surgeons and the method in which we recommend these questions be addressed in the most efficient manner considering time, cost, and quality.