Infertility is an important reproductive issue prevailing in the society because the production of offspring is necessary for the continuation of society. In Pakistan, fertility is related to women and is considered an important part of life. It is assumed that soon after the marriage a couple will prove itself to be fruitful. The present study was conducted to deal with the various aspects of individual's life which are affected by infertility. It highlighted the causes of infertility in males and females and what are the psychological and social problems of infertile among the couple. Infertility is not a problem of a single person rather it affects both partners and how infertility affects the relationship of husband and wife was also studied. The basic aim of the study was to explore the stigmatization of infertility among the infertile couples in Islamabad. Infertility threatened the individual to be labeled as incomplete, useless, barren and abnormal person, which caused lack of confidence, respect and loss of status in the society. The social support by the family, friends and partners has however, played a vital role in dealing with stigmatization.