Molecularly imprinted polymers (MIPs) are synthetic polymers possessing specific recognition sites designed for a template molecule. These artificially-generated recognition sites have their shapes, sizes or functionalities complementary to the template, and are capable of rebinding the template in preference to other closely analogue. The main propose of this study is to prepare a series of the molecularly imprinted polymers based on siloxanes for recognized sulfonamide by sol-gel process and to investigate systematically their preparation conditions and the various fundamental properties. This book contains three parts as follows: in first part, the sol-gel molecularly imprinted polymers based on tetramethoxysilane (TMOS) and methyltrimethoxysilane (MTMOS) for recognized sulfonamides were prepared. In second part, the synthesis of a molecularly imprinted polymers composed of tetraethoxysilane (TEOS) for recognized sulfonamides using a single-step sol-gel process were studied. In third part, the synthesis of molecularly imprinted polymers composed of tetraethoxysilane (TEOS) for recognized sulfonamides using a two-step sol-gel process were investigated.