This book contains a comprehensive series of reviews on the calcitonin gene-related peptide (CGRP) family of peptides. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition.

This volume includes chapters on:


The adrenomedullin peptides and signalling


Ligand binding and activation of the CGRP receptor


Understanding amylin receptors


The CGRP-receptor component protein


The calcitonin peptide family


Genetic regulation of CGRP


Vascular actions of CGRP and adrenomedullin


Intermedin/adrenomedullin 2 function


CGRP and adrenomedullin as pain-related peptides


Amylinergic control of ingestive behaviour


Calcitonin receptors


This book discusses their receptors, physiological and pathophysiological functions and potential as clinical targets. It will appeal to researchers who study any of these peptides and those with an interest in migraine therapy due to the involvement of CGRP in this disorder. The book is unique because it brings together research on the whole peptide family for the first time in several years. It will be a useful reference volume for researchers in this area. This book will also appeal to researchers in the broader field of bioactive peptides.