It's a bad idea for a drug courier on the job to pick up a woman in a roadside bar. Cyril learns this lesson the hard way when the sultry-voiced girl he brings back to his motel room holds him up at gunpoint. In the meantime Danny, a fast talking sex-offender, has Cyril's car remotely tracked. He enlists the help of his over-sized neighbor Derek to hunt down Cyril and grab the cash, but they run into problems of their own on the unfamiliar highways of the Midwest. Soon Cyril's sinister brother Duane and his mysterious partner Inez also join the chase, but no one seems to understand that Cyril hasn't even made his pickup yet. Willow and Cyril form an uneasy alliance based on necessity, lust, and the desire for a quick payday. But with so many dangerous players giving chase, will they nab their package?