Sequel to Serum of the Dead. A town's biggest nightmare continues with a new terror.

In a small town, a group of survivors escaped one horror to face another as they fight for their lives.

Margie Barnes' bite wound takes her body through changes that have the local medical staff stumped. Doctor Fredrick Blake consults on her unique condition, which only he may be able to shed light on. Margie's physiological changes turn her into something between the living and the dead. She starts a new dead army, unleashing the terror on a new town of unaware citizens. Sheriff Rob Daniels and Reverend Theodor Brighton lead the living in a new battle against the dead. They rely on the experienced survivors to see them through and build a new weapon in time.