The application of molecular biologic methods, recognition of neurogenic inflammatory processes, and utilization of genetic knockout animals are just some of the advances in toxicology of the upper airways in recent years. This book represents a culmination of knowledge gained from human and experimental animal studies over the past decade. It examines the effect of selected pollutants on the upper airways of humans and animals and epidemiologic findings from populations exposed occupationally or environmentally. Chapters are organized into clear sections on structure and function, dosimetry and toxicokinetics, functional and pathologic responses and their measurement, responses to specific agents, risk assessment, and special topics.