The triple helix of university¿industry¿government interactions is a universal model of the development of the knowledge-based society, through innovation and entrepreneurship. Triple helix, the secret of an innovative region, may also be found in Statist or Laissez-faire societies, globally. The Triple Helix as a universal innovation model can assist students, researchers, managers, entrepreneurs, and policymakers to understand the roles of university, industry, and government in forming and developing ¿an innovative region, ¿ which has self-renewal and sustainably innovative capacity.