A complete update on the safety testing of foods, drugs, and chemicals in laboratory animals, featuring: - a thorough review of each subject area with extensive revision in line with new information and concepts - electron micrographs in exquisite detail to illustrate results of recent research - the effects of many carcinogens described succinctly and illustrated in detail - neoplasms described in detail and compared with natural and induced tumours in other species - standardised nomenclature. Of interest to those interested in the many applications to human patients, Urinary System: - facilitates uniform interpretation of bioassay results world-wide - provides a basis for understanding mechanisms involved in the functions and malfunctions of the most minute, but important structures of the kidneys - explains the functional significance of details by identifying the composition of structures at the molecular level. Forming a solid basis for understanding the causes and effects of disease of the urinary system, this is essential reading for pathologists, toxicologists, regulatory agencies, and all those involved in carcinogenicity and toxicity studies.